Redartz: Greetings, friends! Or should I say 'buddies'? Perhaps so, because today we are considering the best pals in comicdom. I've chosen three pairs, one from each of three companies (yes, I'm a bit obsessive/compulsive). But that leaves you all free to come up with other famous four-color friendships...
Representing Marvel: who else but Spider-Man and the Human Torch? Almost from his first appearance, Spidey had a love/hate relationship with Johnny Storm. And of course, Johnny was responsible for helping devise the Spider-Mobile. A friend, indeed...

From DC: Green Lantern and Green Arrow, aka the 'Hal and Ollie' show. Speaking of love/hate relationships, Hal and Ollie seem to bicker over the years perhaps more than they pal around. Personality conficts, I guess...
And from Archie: Obviously, Archie and Jughead! Definitely more in tune with each other than Hal Jordan and Oliver Queen, Archie Andrews and Forsyte Jones have personified friendship for many decades...

Those are the first that came to my mind. How many more can you come up with?